Vancomycin Hydrochloride as a Risk Factor for Acute Kidney Injury: A Retrospective Study.

Shusuke Uekusa,Yuki Hanai, Shinobu Hirayama,Takuya Yokoo,Tetsuya Hasegawa, Kohei Shimoyama, Ayumu Kusano,Kenji Nishizawa,Takahiro Matsumoto,Kazuhiro Matsuo

Pharmacology（2023）

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摘要

Our study demonstrated that high serum VCM trough concentrations and the combination of VCM and TZP were independent risk factors for VCM-induced AKI. Avoiding the concomitant use of TZP, or thorough monitoring of renal function with the concomitant use of TZP, may be helpful in reducing the occurrence of AKI. Furthermore, monitoring serum VCM trough concentrations within 2 days may effectively reduce the incidence of AKI.

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关键词

Piperacillin-tazobactam, Pharmacokinetics, Nephrotoxicity, Therapeutic drug monitoring, Vancomycin

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