Tumor microenvironment modifications induced by afatinib in squamous cell carcinoma of the head and neck - a window-of-opportunity study (EORTC90111-24111).

Simon P Beyaert,Axelle E Loriot,Nicolas D Huyghe, Rose M Goebbels,Antonella Mendola, Anne-Sophie Govaerts,Catherine Fortpied,Pamela Baldin,Lisa F Licitra,Yassine Lalami,Paul M Clement,Jean-Pascal H Machiels,Sandra Schmitz

Clinical cancer research : an official journal of the American Association for Cancer Research（2023）

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摘要

Short-term treatment with afatinib in primary HNSCC induces CD3+ and CD8+ tumor infiltration and, in some patients, EMT and CAFs activation. These results open perspectives to overcome resistance mechanisms to anti-HER therapy and to potentiate the activity of immune checkpoint inhibitors.

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