Clinical Study of Modified Zhitong Jiangu Decoction(加减止痛健骨方)Combined with Calcitonin in Treatment of Knee Osteoarthritis with Osteoporosis
Liaoning Journal of Traditional Chinese Medicine(2021)
Abstract
目的 研究加减止痛健骨方联合依降钙素治疗膝骨关节炎合并骨质疏松症的临床疗效.方法 选取在医院就诊的膝骨关节炎合并骨质疏松症患者78例,随机分成对照组和治疗组两组,对照组予以依降钙素注射治疗,治疗组采用依降钙素联合加减止痛健骨方治疗,两组疗程均8周,并随访至停药后8周.比较两组治疗效果、Lysholm膝关节评分、VAS评分、BMD、膝关节液IL-6、血清BGP水平.结果 用药8周和16周后,两组治疗效果、Lysholm评分、BMD、BGP高于治疗前(P<0.05),VAS评分、IL-6低于治疗前(P<0.05);治疗组治疗效果、Lysholm评分、BMD、BGP高于对照组(P<0.05),VAS评分、IL-6低于对照组(P<0.05).结论 加减止痛健骨方联合依降钙素注射液具有提高疗效,改善膝关节功能,提高骨密度,降低关节液炎性因子等良好的临床效果,且疗效药效至少能维持8周.
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