Sulfur fluoride exchange

Click chemistry is a conceptual strategy to rapidly synthesize and discover functional molecules. Sulfur fluoride exchange (SuFEx) is a click reaction that has revolutionized multiple research fields. In this Primer, we delve into the essential elements of SuFEx operation, catalysis and SuFExable connective hubs. We also explore the cutting-edge applications of SuFEx in drug development, polymer science and biochemistry. Additionally, we examine the potential limitations and promising prospects for this versatile click reaction.