The association between proton pump inhibitors and hyperparathyroidism: a potential mechanism for increased fracture-results of a large observational cohort study.

Donal Fitzpatrick,Rosaleen Lannon,Eamon Laird,Mary Ward,Leane Hoey,Catherine F Hughes,J J Strain,Conal Cunningham,Helene McNulty,Anne M Molloy,Kevin McCarroll

Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA（2023）

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摘要

The results are consistent with the hypothesis of PPIs reducing calcium absorption, leading to a rise in PTH which could mediate increased fracture risk. No relationship of PPI use with hyperparathyroidism was observed in non-users of calcium supplements, possibly owing to lower dietary calcium intake. These results highlight the importance of monitoring PPI use, especially in older adults at risk of fracture.

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Calcium absorption, Hyperparathyroidism, Osteoporosis, Proton pump inhibitor

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