Favorable prognostic impact of phosphatase and tensin homolog alterations in wild-type isocitrate dehydrogenase and telomerase reverse transcriptase promoter glioblastoma.

Nayuta Higa,Toshiaki Akahane,Seiya Yokoyama,Ryutaro Makino,Hajime Yonezawa,Hiroyuki Uchida,Tomoko Takajo,Mari Kirishima,Taiji Hamada,Naoki Noguchi,Ryosuke Otsuji,Daisuke Kuga, Shohei Nagasaka,Hitoshi Yamahata,Junkoh Yamamoto,Koji Yoshimoto,Akihide Tanimoto,Ryosuke Hanaya

Neuro-oncology advances（2023）

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摘要

Here, we report that loss and/or mutation is the most useful marker for predicting favorable outcomes in patients with - and -wild-type glioblastomas. The combination of 4 genes, , , , and , is important for the molecular classification and individual prognosis of patients with - and -wild-type glioblastomas.

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PTEN, prognostic markers, TERTp, TERTp-wild-type glioblastoma

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