Determination of PDK1, SLC2A1, EGFR, PTEN, CD276 Gene Expression Levels and IDH1 Gene R132H Polymorphism in Brain Tumor Tissues.

We determined similar findings for the previously reported PDK1, EGFR, PTEN, and CD276 gene expression levels. In contrast, SLC2A1 gene expression was downregulated remarkably, as reported in other tumor studies. These findings may be due to the unique nature of brain tumor tissues. Additionally, a decrease in PTEN gene expression was determined in grade IV brain tumors, including glioblastoma and meningioma. Although the size of the analyzed study group was limited, the gene expression results show similarities in behaviors of genes in cancer staging.