Diagnostic performance of F-FDG PET or PET/CT 18 for detection of myocarditis

Objective: The purpose of the current study was to evaluate the diagnostic accuracies of fluorine-18-flu-orodeoxyglucose ( F-FDG) positron emission tomography (PET) or PET/computed tomography (CT) for 18 diagnosis of myocarditis through and a meta-analysis. Materials and Methods: The PubMed, Cochrane database, and Embase database were searched from inception through November 30, 2022 for studies evaluating diagnostic performance of F-FDG PET or PET/CT for diagnosis of acute myocarditis. Based on 18 data extracted from patient-based analysis, we calculated the pooled sensitivity and specificity with the 95% confidence intervals (CI). Also, we calculated positive and negative likelihood ratios (LR+ and LR-), and constructed summary receiver operating characteristic curves. Results: Across 5 studies (6 results, 264 pa-tients), the pooled sensitivity of F-FDG PET or PET/CT was 0.57 (95% CI; 0.26-0.84) and a pooled specificity 18 of 0.89 (95% CI; 0.74-0.96). Likelihood ratio (LR) syntheses gave an overall positive likelihood ratio (LR+) of 5.1 and negative likelihood ratio (LR-) of 0.48. The pooled DOR was 11 (95% CI; 2-47). In meta-regression analysis, no variable was the source of the study heterogeneity. Conclusions: Fluorine-18-FDG PET or PET/ CT showed insufficient sensitivity and moderate specificity for diagnosis of myocarditis. These results indi-cated that cautious application of F-FDG PET or PET/CT should be paid for detection of myocarditis. 18