Myocardial Fibrosis and Cardiomyopathy Risk: A Genetic Link in the MESA.

Mahsima Shabani,Min Wang,Gregory D Jenkins,Jerome I Rotter,Stephen S Rich,Anthony Batzler,Kent D Taylor,Josyf C Mychaleckyj,Duan Liu,Joao A C Lima,Naveen L Pereira

Circulation. Heart failure（2023）

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摘要

Common genetic variation in previously associated with risk for cardiomyopathies and increased LV wall thickness is associated with increased cardiac magnetic resonance imaging-based myocardial fibrosis and increased TGF-β1 mediated myocardial fibrosis in vitro. Whether these findings suggest a pathophysiologic link between myocardial fibrosis and cardiomyopathy risk remains to be proven.

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