Clinical prospective intra-individual comparison after mix-and-match implantation of a monofocal EDOF and a diffractive trifocal IOL

Objectives To assess intra-individually visual acuity (VA) and subjective outcome after mix-and-match implantation of a monofocal EDOF IOL and a diffractive trifocal IOL. Methods The monofocal EDOF Isopure IOL was implanted in the dominant eye and the trifocal FineVision HP IOL in the non-dominant eye. Postoperative evaluation included VA at various distances, contrast acuity, monocular defocus curves, decentration and tilt, wavefront aberrometry, VF-7 questionnaire and a halo and glare simulator. Results 50 eyes of 25 subjects were enroled. The trifocal IOL performed better at monocular DCNVA ( p < 0.01) and at defocus levels of –1.5D to –4.0D ( p < 0.01), the monofocal EDOF IOL was better at –0.5D ( p = 0.013). No differences in monocular BCDVA, DCIVA, contrast acuity, decentration or tilt were observed ( p > 0.05). Wavefront analysis revealed lower HOAs in the trifocal group at 5 mm ( p < 0.01) and no difference ( p = 0.107) at 3 mm pupil aperture. The monofocal EDOF IOL displayed increased negative SA at 5 mm ( p < 0.01) and 3 mm ( p < 0.01) pupil diameter. Low values of optical phenomena and satisfying results of the VF-7 questionnaire were obtained. Conclusion Excellent visual performance and low rates of optical phenomena were achieved after mix-and-match implantation of the monofocal EDOF Isopure IOL and the trifocal FineVision HP IOL. Trifocal IOL implantation in the non-dominant eye may decrease optical disturbing phenomena. Similar results were observed for monocular distance, intermediate and contrast VA. The trifocal IOL provided better monocular near VA. Decentration and tilt and HOAs were low.