Fluorene-based tau fibrillation sensor and inhibitor with fluorogenic and photo-crosslinking properties.

Qiuxuan Xia,Zhiming Wang,Wang Wan,Huan Feng,Rui Sun,Biao Jing,Yusong Ge,Yu Liu

Chemical communications (Cambridge, England)（2023）

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摘要

Tau protein aggregation into neurofibrillary tangles often causes tauopathies. Herein, we report fluorene based sensors with fluorogenicity upon binding to tau proteins. Intriguingly, these sensors possess triplet state properties to inhibit tau fibrillation upon photo-induced crosslinking.

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关键词

tau fibrillation sensor,fluorogenic,fluorene-based,photo-crosslinking

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