Plasma Membrane Channel TRPM4 Mediates Immunogenic Therapy-Induced Necrosis.

Santanu Ghosh,Rachel Yang,Darjan Duraki,Junyao Zhu,Ji Eun Kim,Musarrat Jabeen,Chengjian Mao, Xinyi Dai,Mara R Livezey,Matthew W Boudreau,Ben H Park,Erik R Nelson,Paul J Hergenrother,David J Shapiro

Cancer research（2023）

Cited 0|Views11

No score

Abstract

A genome-wide CRISPR screen reveals a pivotal role for TRPM4 in cell death and immune activation following treatment with diverse necrosis-inducing anticancer therapies, which could facilitate development of necrosis-based cancer immunotherapies.

Translated text

AI Read Science

Must-Reading Tree

Example

Generate MRT to find the research sequence of this paper

Chat Paper

Summary is being generated by the instructions you defined