Angiotensin ii type 1 receptor antibody mediated kidney rejection unresponsive to treatment
Cureus(2023)
Abstract
Allograft rejection is a significant cause of renal transplant failure which needs prompt diagnosis and treatment for graft salvage. Angiotensin II type 1 receptor antibody-mediated rejection (AT1R-AMR) is increasingly being identified as the etiology of antibody-mediated rejection in kidney transplant recipients with allograft rejection but without detectable human leukocyte antigen (HLA) antibodies. While some reports have suggested that AT1R-AMR may be refractory to standard therapy, others have reported improvement or stabilization of graft function. We present two patients in which anti-rejection therapy including therapeutic plasma exchange was unable to salvage the allograft.
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Key words
renal transplant rejection, apheresis therapy, at1r antibody, non-hla antibody, kidney allograft, therapeutic plasma exchange (tpe)
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