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Use of Saccharomyces boulardii CNCM I-745 as therapeutic strategy for prevention of nonsteroidal anti-inflammatory drug-induced intestinal injury.

Vanessa D'Antongiovanni,Luca Antonioli,Laura Benvenuti,Carolina Pellegrini,Clelia Di Salvo,Marco Calvigioni,Adelaide Panattoni,Larisa Ryskalin,Gianfranco Natale,Sebastiano Banni,Gianfranca Carta,Emilia Ghelardi,Matteo Fornai

British journal of pharmacology（2023）

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Abstract
Treatment with S. boulardii CNCM I-745 prevents diclofenac-induced enteropathy through anti-inflammatory and antioxidant activities. Such effects are likely to be related to increased tissue butyrate bioavailability, through an improvement of butyrate uptake by the enteric mucosa.
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Key words
enteropathy, intestinal damage, microbiota, nonsteroidal anti-inflammatory drugs, probiotics, Saccharomyces boulardii
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