FGD5-AS1/miR-5590-3p/PINK1 induces Lenvatinib resistance in hepatocellular carcinoma

Meifang Song,Luyuan Ma,Chuan Shen,Wenpeng Liu, Pengfei Zhang,Ranran Bi,Caiyan Zhao

Cellular signalling（2023）

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摘要

•PINK1 related to the mitochondrial homeostasis is a new molecule of lenvatinib resistance.•FGD5-AS1 is the upstream regulatory factor of PINK1.•FGD5-AS1 regulates PINK1 expression by sponging miR-5590-3p in HCC cells.•FGD5-AS1/miR-5590-3p/PINK1 affects mitochondrial homeostasis to induce lenvatinib resistance in HCC.

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关键词

FGD5-AS1,miR-5590-3p,PINK1,Hepatocellular carcinoma,Lenvatinib,Resistance

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