Aortic valve calcification is promoted by interleukin-8 and restricted through antagonizing CXCR2.

Kawthar Dhayni,Yuthiline Chabry,Lucie Hénaut,Carine Avondo,Cedric Boudot, Hakim Ouled-Haddou, Edith Bigot-Corbel,Gilles Touati,Thierry Caus, Hind Messaoudi,Jérémy Bellien, Christophe Tribouilloy, David Messika-Zeitoun,Kazem Zibara,Saïd Kamel,Youssef Bennis

Cardiovascular research（2023）

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摘要

Overall, these results highlight, for the first time, a significant role for IL-8 in the progression of CAVD by promoting calcification via a CXCR2-- and MMP-12-dependent mechanism that leads to elastin degradation, and identify CXCR2 as a promising therapeutic target for the treatment of CAVD.

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