Histiocytic Sarcoma of Submandibular Gland: A Rare Case Report

Histiocytic Sarcoma (HS) is a rare malignant neoplasm characterised by the neoplastic proliferation of cells showing morphological and immunophenotypic features of mature histiocytes. Majority of the reported cases present in extranodal sites, such as the head and neck, thyroid, duodenum, small intestine, colon, urinary bladder, spleen, and leptomeninges. This report documents a case of primary involvement of the salivary gland by HS. A 77-year-old male patient presented with a firm swelling in the left submandibular region for the last three months. Multiple lymph nodes, along with the presence of lung and liver nodules, were seen. Thus the final diagnosis of HS was made based on histopathology and IHC. Palliative chemotherapy was given to the patient, responded well, and has been well for the last year. The present study is probably the first case of HS involving the submandibular gland.