Biomembranomics at Molecular Level: A New Generation of Biomics

Biomics is an important research means to reveal the laws of life and human health. However, it is essentially a large-scale feature study at the overall level, and cannot be directly used for disease diagnosis and treatment. Therefore, it is urgent to establish a new omics system to study the structure, location, orderly interaction and dynamic function of biomolecules at the molecular level. As the basic unit of life structure, cells are defined by biomembranes. The biomembranes form an important barrier between living cells and the surrounding environment, and separate organelles in eukaryotic cells. The study of membrane structure has a history of nearly one hundred years. Although many models of cell membrane structure have been proposed, they are still in the stage of model hypothesis. Because the structure, function and interaction between membrane components are indivisible organic whole, the research on one aspect alone cannot uncover the biomembrane system in essence. Based on this, this paper proposed a new concept of & DPRIME;biomembromics & DPRIME;, which regarded the structure, function and intermolecular interaction of membrane system as an organic whole, and established a new and real membrane structure at the molecular level. In addition, the latest progress in the researches of membrane structure, properties and functions at the molecular level were summarized. Finally, the development trend, opportunities and challenges of biomembranomics were discussed.