The Cryo-EM Structure of Renal Amyloid Fibril Suggests Structurally Homogeneous Multiorgan Aggregation in AL Amyloidosis

•In AL amyloidosis, light chains independently form amyloids in different organs.•4.0 Å cryo-EM structure of amyloid fibrils from the kidney of an AL patient.•Amyloids from kidneys and from heart of the same AL patient share a common fold.•AL deposits from different organs of a patient may generally share the same amyloid fold.