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First evidence of in vivo effect of FLASH radiotherapy with helium ions in zebrafish embryos.

Youssef Ghannam,Sophie Chiavassa,Gaëlle Saade,Charbel Koumeir,Guillaume Blain,Grégory Delpon,Manon Evin,Ferid Haddad,Lydia Maigne,Quentin Mouchard,Noël Servagent,Vincent Potiron,Stéphane Supiot

Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology（2023）

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Abstract
The ability to reduce toxicity of ultra-high dose rate (UHDR) helium ion irradiation has not been reported in vivo. Here, we tested UHDR helium ion irradiation in an embryonic zebrafish model. Our results show that UHDR helium ions spare body development and reduce spine curvature, compared to conventional dose rate.
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