Antecedents to first episode psychosis and mania: Comparing the initial prodromes of schizophrenia and bipolar disorder in a retrospective population cohort

Javier Ortiz-Orendain,Manuel Gardea-Resendez,Santiago Castiello-de Obeso,Raphael Golebiowski,Brandon Coombes, Peggy M. Gruhlke, Ian Michel,J. Michael Bostwick,Robert J. Morgan,Aysegul Ozerdem,Mark A. Frye,Alastair J. McKean

JOURNAL OF AFFECTIVE DISORDERS（2023）

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摘要

•Most cases of schizophrenia (SZ) and bipolar disorder (BD) have psychiatric antecedents before the first episode.•The psychiatric antecedents of SZ and BD are heterogenous and start during adolescence.•The mental health problems before the onset of SZ and BD are more alike than different.

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关键词

Bipolar disorder,Schizophrenia,Prodrome,Cohort studies,First episode

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