Hypervalent Iodine Mediated Synthesis of Sulfinamidines from Sulfenamides

In this study, we present a novel, efficient method forthe oxidativeamination of sulfenamides using diacetoxyiodobenzene (PhI(OAc)(2)) and amines under basic conditions. This innovative techniquestreamlines the synthesis of sulfinamidines under mild, metal-freeconditions, achieving outstanding yields of up to 99%. Furthermore,we propose possible pathways that elucidate the observed molecularsequence of events in this reaction. This cutting-edge approach notonly advances the synthesis of valuable sulfinamidine compounds butalso expands the synthetic toolbox available to chemists, paving theway for future discoveries in organic synthesis and potential applicationsin medicinal chemistry.