Subclones with variants of uncertain clinical significance might contribute to ineffective hemopoiesis and leukemia predisposition.

Valentina Giudice,Bianca Serio,Santa Errichiello,Idalucia Ferrara,Alessandra Galdiero,Angela Bertolini,Roberta Visconti,Danilo De Novellis,Roberto Guariglia,Serena Luponio,Denise Morini,Anna Maria Della Corte,Anna Maria Sessa,Francesco Verdesca,Maddalena Langella,Barbara Izzo,Carmine Selleri

European journal of haematology（2023）

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摘要

In conclusions, we linked both pathogenic and VUS variants in AML-related genes to clonal hematopoiesis; therefore, we proposed to consider those variants as prognostic markers in leukemia and myelodysplasia. However, further studies in larger prospective cohorts are required to validate our results.

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关键词

acute myeloid leukemia,clonal hematopoiesis,myelodysplastic syndromes,pathogenic mutations,variants of uncertain significance

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