Synthesis of P‑Stereogenic Phosphinamides via Pd(II)-Catalyzed Enantioselective C–H Alkynylation

P-Stereogenic phosphinamides representimportantstructural elements in chiral organocatalysts and bioactive compounds.Herein, we report Pd(II)-catalyzed enantioselective C-H alkynylationusing cheap commercially available l-pyroglutamic acid asa chiral ligand. A range of structurally diverse P-stereogenic phosphinamides was prepared in good yields with highenantioselectivities via desymmetrization and kinetic resolution.A tailor-made congested directing group, N-ethyl-N-(3-methylpyridin-2-yl)amino, was crucial for the reactivity.