A supramolecular hydrogel based on the combination of YIGSR and RGD enhances mesenchymal stem cells paracrine function via integrin α2β1 and PI3K/AKT signaling pathway for acute kidney injury therapy

Qiuxia Han,Sifan Ai,Quan Hong,Chuyue Zhang,Yanqi Song,Xiaochen Wang,Xu Wang,Shaoyuan Cui,Zongjin Li,Hanyu Zhu,Zhimou Yang,Xiangmei Chen,Guangyan Cai

Chemical Engineering Journal（2022）

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摘要

•YIGSR and RGD peptides were conjugated to form a novel YIGSRGD peptide for MSC-based therapy.•Novel biotin-DFYIGSRGD hydrogel provides stability and structural support to MSCs.•Biotin-DFYIGSRGD enhances the anti-apoptotic and anti-inflammatory effects of MSCs.•Biotin-DFYIGSRGD improves the survival and therapeutic effects of MSCs.•The proposed hydrogel promotes kidney regeneration in AKI model.

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关键词

Peptides,Hydrogel,Integrin,Mesenchymal stem cell,Acute kidney injury

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