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Inhibition of PHLPP1/2 phosphatases rescues pancreatic β-cells in diabetes

Blaz Lupse,Karthika Annamalai,Hazem Ibrahim,Supreet Kaur, Shirin Geravandi, Bhavishya Sarma,Anasua Pal,Sushil Awal,Arundhati Joshi,Sahar Rafizadeh, Murali Krishna Madduri,Mona Khazaei,Huan Liu,Ting Yuan,Wei He,Kanaka Durga Devi Gorrepati,Zahra Azizi,Qi Qi,Keqiang Ye,Jose Oberholzer

Cell Reports（2021）

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关键词
beta cell,type 2 diabetes,T2D,pleckstrin homology domain leucine-rich repeat protein phosphatases 1 and 2,PHLPP1/2,apoptosis,MST1,AKT,MTORC1,insulin
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