Searching for molecular hypoxia sensors among oxygen-dependent enzymes

ELIFE(2023)

引用 1|浏览2
暂无评分
摘要
The ability to sense and respond to changes in cellular oxygen levels is critical for aerobic organisms and requires a molecular oxygen sensor. The prototypical sensor is the oxygen-dependent enzyme PHD: hypoxia inhibits its ability to hydroxylate the transcription factor HIF, causing HIF to accumulate and trigger the classic HIF-dependent hypoxia response. A small handful of other oxygen sensors are known, all of which are oxygen-dependent enzymes. However, hundreds of oxygen-dependent enzymes exist among aerobic organisms, raising the possibility that additional sensors remain to be discovered. This review summarizes known and potential hypoxia sensors among human O-2-dependent enzymes and highlights their possible roles in hypoxia-related adaptation and diseases.
更多
查看译文
关键词
molecular hypoxia sensors,enzymes,oxygen-dependent
AI 理解论文
溯源树
样例
生成溯源树,研究论文发展脉络
Chat Paper
正在生成论文摘要