Asymmetric Total Synthesis of Cephalotaxus Diterpenoids: Cephinoid P, Cephafortoid A, 14-epi-Cephafortoid A and Fortalpinoids M-N, P
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY(2023)
Abstract
The asymmetric total syntheses of cephalotaxus C19 diterpenoids, bearing a unique cycloheptene A ring with a chiralmethyl group at C-12, were disclosed based on a universal strategy.Six members, including cephinoid P, cephafortoid A, 14-epi-cephafortoid A and fortalpinoids M-N, P, were accomplished for thefirst time. The concise approach relies on two crucial steps: (1)a Nicholas/Hosomi-Sakurai cascade reaction was developed to efficientlygenerate the cycloheptene ring bearing a chiral methyl group; (2)an intramolecular Pauson-Khand reaction was followed to facilitatethe construction of the complete skeleton of target molecules. Ourstudies provide a new strategy for the synthetic analysis of cephalotaxus diterpenoids and structurally related polycyclicnatural products.
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Key words
diterpenoids,total synthesis
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