Leveraging translational insights toward precision medicine approaches for brain metastases

Due to increasing incidence and limited treatments, brain metastases (BM) are an emerging unmet need in modern oncology. Development of effective therapeutics has been hindered by unique challenges. Individual steps of the brain metastatic cascade are driven by distinctive biological processes, suggesting that BM possess intrinsic biological differences compared to primary tumors. Here, we discuss the unique physiology and metabolic constraints specific to BM as well as emerging treatment strategies that leverage potential vulnerabilities. Brastianos and colleagues discuss the molecular and microenvironmental features of brain metastases, as well as promising avenues in translational research to overcome challenges for effective treatments.