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αKlotho decreases after reduced weight-bearing from both spaceflight and hindlimb unloading

Jeffrey S. Willey,Serena Aunon-Chancellor, Lauren A. Miles,Joseph E. Moore,Xiao W. Mao, Robert W. Wallace,Matthew C. Foy

npj Microgravity（2022）

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Abstract
Alpha(α)Klotho, a soluble transmembrane protein, facilitates calcium-phosphorus homeostasis through feedback between bone and kidney and is a potential systemic biomarker for bone-kidney health during spaceflight. We determined if: (1) plasma αKlotho was reduced after both spaceflight aboard the ISS and hindlimb unloading (HU); and (2) deficiency could be reversed with exercise. Both spaceflight and HU lowered circulating plasma αKlotho: plasma αKlotho recovered with exercise after HU.
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