Role of Proviral HIV-1 DNA Genotyping for People Living with HIV (PLWH) Who Had Low-Level Viremia While Receiving Antiretroviral Therapy.

Shiyun Lv,Lijun Sun,Tongzeng Li,Ruojing Bai,Man Dai,Ran Wang, Yuanyi Zhai,Wei Hua,Aixin Li,Ruolei Xin,Lili Dai

Infection and drug resistance（2023）

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摘要

We found that the concordance between proviral DNA and past and synchronous RNA genotyping was moderate. Proviral DNA genotyping lost than gained more information on antiretroviral resistance compared with past or synchronous RNA genotyping. To optimize ART in PLWH with LLV, antiretroviral resistance profile should be interpreted in combination with proviral DNA and RNA genotyping and a comprehensive review of previous treatment history.

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关键词

genotypic resistance testing, resistance-associated mutation, nucleoside reverse-transcriptase inhibitor, non-nucleoside reverse-transcriptase inhibitor, protease inhibitor

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