Autologous humanized PDX modeling for immuno-oncology recapitulates features of the human tumor microenvironment.
Journal for immunotherapy of cancer（2023）
摘要
Humanization of the interleukin 6 locus in MISTRG6 mice enhances HSPC engraftment, making it feasible to model tumor-immune interactions in an autologous manner from a bedside bone marrow aspirate. The TME from these autologous tumors display hallmarks of the human TME including innate and adaptive immune activation and provide a platform for preclinical drug testing.
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关键词
Immunity, Innate, Immunotherapy, Inflammation, Macrophages, Tumor Microenvironment
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