Risk of metastasis in BRCA2 carriers diagnosed with triple-negative breast cancer.

Marcelo Moreno, Júlia Salles Oliveira,Rafael Canfield Brianese,Douglas Guedes de Castro,Solange Moraes Sanches,Giovana Tardin Torrezan,Karina Miranda Santiago,Marina De Brot,Vladmir Claudio Cordeiro de Lima,Fabiana Baroni Alves Makdissi,Jose Claudio Casali Da Rocha,Vinicius Fernando Calsavara,Dirce Maria Carraro

Cancer medicine（2023）

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摘要

Patients with TNBC and PV in the BRCA2 gene had higher frequencies of secondary bone involvement and CNS in the course of the disease. However, the BRCA2 PV did not represent an independent outcome predictor of metastases and overall survival. Efforts to increase the number of BRCA2 carriers among TNBC patients are crucial for determining their risk of developing bone and CNS metastases compared to BRCA2 noncarriers.

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关键词

BRCA mutations, BRCA1 gene, BRCA2 gene, breast cancer, metastasis

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