Maternal protein deficiency alters primary cilia length in renal tubular and impairs kidney development in fetal rat.

Jun Wang,Pei Zhou,Liangliang Zhu,Hongbo Guan,Jian Gou,Xiaomei Liu

Frontiers in nutrition（2023）

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Abstract

We elucidated that intrauterine protein malnutrition led to deregulation of ciliogenesis factors and cilia elongation in renal tubular epithelial, inhibited β-catenin signaling, and induced cell apoptosis and ultimately, compromised kidney development.

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Key words

FGR, kidney, primary cilia, IFT88, DYNLT1, beta-catenin pathway

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