Efficacy of Adjunctive Therapy with Zonisamide Versus Increased Dose of Levodopa for Motor Symptoms in Patients with Dementia with Lewy Bodies: The Randomized, Controlled, Non-Inferiority DUEL Study.
Journal of Alzheimer's disease : JAD（2023）
Abstract
Adjunct zonisamide 25 mg/day may yield moderate improvement for motor symptoms in patients with DLB when the levodopa effect is insufficient, but it could not be verified that the zonisamide 25 mg/day was as effective as levodopa 100 mg/day because levodopa showed no sufficient efficacy as assumed.
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Key words
levodopa,dementia,zonisamide versus increased dose,lewy bodies,adjunctive therapy,non-inferiority
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