An individual-based model to explore the impact of psychological stress on immune infiltration into tumour spheroids
arxiv(2023)
摘要
In recent in vitro experiments on co-culture between breast tumour spheroids
and activated immune cells, it was observed that the introduction of the stress
hormone cortisol resulted in a decreased immune cell infiltration into the
spheroids. Moreover, the presence of cortisol deregulated the normal levels of
the pro- and anti-inflammatory cytokines IFN-γ and IL-10. We present an
individual-based model to explore the interaction dynamics between tumour and
immune cells under psychological stress conditions. With our model, we explore
the processes underlying the emergence of different levels of immune
infiltration, with particular focus on the biological mechanisms regulated by
IFN-γ and IL-10. The set-up of numerical simulations is defined to mimic
the scenarios considered in the experimental study. Similarly to the
experimental quantitative analysis, we compute a score that quantifies the
level of immune cell infiltration into the tumour. The results of numerical
simulations indicate that the motility of immune cells, their capability to
infiltrate through tumour cells, their growth rate and the interplay between
these cell parameters can affect the level of immune cell infiltration in
different ways. Ultimately, numerical simulations of this model support a
deeper understanding of the impact of biological stress-induced mechanisms on
immune infiltration.
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