芍药苷对荷瘤小鼠化疗的减毒增效作用研究
SHAANXI JOURNAL OF TRADITIONAL CHINESE MEDICINE(2011)
Abstract
目的:研究芍药苷对环磷酰胺(CTX)化疗S180荷瘤小鼠的减毒和增效作用.方法:建立小鼠体内移植性实体瘤模型,观察芍药苷与化疗药物合用对瘤体重量、小鼠的体重,外周血白细胞(WBC)数、骨髓有核细胞数的影响.结果:芍药苷能可明显对抗CTX化疗引起的体重减少,增强化疗药物抑瘤作用、拮抗化疗药物对WBC及骨髓有核细胞的抑制.且升高白细胞作用有明显的剂量关系,剂量越大,升白效果越明显.结论:芍药苷对荷瘤小鼠化疗具有增效、减毒的作用.
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