Targeting Myofibroblasts as a Treatment Modality for Dupuytren Disease.

Mary E Ziegler,Andres Staben, Melinda Lem,Jason Pham,Leonardo Alaniz,Faris F Halaseh, Sabine Obagi,Amber Leis,Alan D Widgerow

The Journal of hand surgery（2023）

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摘要

The combination of PRP and ASCs to induce the differentiation of DMFs into adipocytes may serve to limit surgery to a percutaneous contracture release and biological injection, rather than a moderate or radical fasciectomy, and reduce the recurrence of Dupuytren contracture.

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关键词

Adipose-derived stem cells, Dupuytren disease, fibrosis, myofibroblasts, platelet-rich plasma

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