Discovery of a potent EGFR and ALK dual mutation inhibitor containing N-(3-((4-((2-(cyclopropylsulfinyl)phenyl)amino)pyrimidin-2-yl)amino) phenyl)acrylamide scaffold

Bioorganic Chemistry（2022）

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摘要

A series of EGFR and ALK dual inhibitors containing sulfoxide and cyclopropyl groups were synthesized and evaluated as anticancer agents.

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关键词

dual mutation inhibitor,potent egfr

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