Lupenone improves type 2 diabetic nephropathy by regulating NF-κB pathway-mediated inflammation and TGF-β1/Smad/CTGF-associated fibrosis.

Hongmei Wu,Feng Xu,Xulong Huang,Xiaofen Li,Piao Yu,Lingling Zhang,Xiaosong Yang,Juan Kong,Cheng Zhen,Xiangpei Wang

Phytomedicine : international journal of phytotherapy and phytopharmacology（2023）

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摘要

Lupenone has potential as an innovative drug for preventing and treating diabetic nephropathy. Additionally, it has great value for the utilization of banana peel resources.

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关键词

Lupenone,Type 2 diabetic nephropathy,Renal inflammation,Renal fibrosis,NF-κB pathway, TGF-β1/Smad/CTGF pathway

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