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Exercise improved bone health in aging mice: a role of SIRT1 in regulating autophagy and osteogenic differentiation of BMSCs.

Chengyu Zhu,Haili Ding, Liang Shi,Shihua Zhang,Xiaoyang Tong,Mei Huang,Lifei Liu,Xiaotian Guan,Jun Zou,Yu Yuan,Xi Chen

Frontiers in endocrinology（2023）

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Abstract
Taken together, this study revealed that exercise improved bone health during aging by activating bone formation, which can be attributed to osteogenic differentiation of BMSCs through the activation of SIRT1-mediated autophagy. The mechanisms underlying this effect may involve mechanical loading.
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Key words
bone health,autophagy,osteogenic differentiation,sirt1,aging
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