Disruption in the regulation of casein kinase 2 in circadian rhythm leads to pathological states: cancer, diabetes and neurodegenerative disorders.

Md Zubbair Malik,Mohammed Dashti,Yasmin Fatima,Arshad Channanath,Sumi Elsa John,R K Brojen Singh,Fahd Al-Mulla,Thangavel Alphonse Thanaraj

Frontiers in molecular neuroscience（2023）

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Abstract

We believe that our findings can contribute towards understanding the molecular mechanisms of circadian dysregulation in pathways driven by the PER mutant genes and their pathological states, including cancer, obesity, diabetes, neurodegenerative disorders, and socio-psychological disease.

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Key words

circadian rhythm,casein kinase,diabetes,cancer

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