Disturbance in the reconstitution of distinct T-cell subsets and the incidence of GvHD following allo-HSCT in pediatric patients with non-malignant hematological disorders.

Shideh Namazi Bayegi,Amir Ali Hamidieh,Maryam Behfar,Mahmood Bozorgmehr,Amene Saghazadeh,Nader Tajik,Ali-Akbar Delbandi,Farzaneh Tofighi Zavareh,Samaneh Delavari,Mehdi Shekarabi,Nima Rezaei

Immunology letters（2023）

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摘要

Our findings suggest a possible relationship between the influence of acute GvHD and its prevention on delayed CD4 T-cell reconstitution and, reciprocally, unbalanced regeneration of CD4 and CD8 T-cell subsets in the development of chronic GvHD.

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关键词

hematological,gvhd,pediatric patients,t-cell,allo-hsct,non-malignant

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