Delayed MSC therapy enhances resolution of organized pneumonia induced by antibiotic resistant Klebsiella pneumoniae infection.

Declan Byrnes,Claire Masterson,Jack Brady,Shahd Horie,Sean D McCarthy,Hector Gonzalez,Daniel O'Toole,John Laffey

Frontiers in medicine（2023）

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摘要

Delayed MSC therapy enhanced resolution of lung injury induced by antibiotic resistant infection and favorably modulated immune cell profile. Overall, AD-MSCs were less effective than either UC- or BM-MSCs, while naïve MSCs had a more favorable effect profile compared to pre-activated MSCs.

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mesenchymal stromal cells,sepsis,immune tolerance,pneumonia,fibrosis,rodent animal models

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