Host-pathogen relationship in retreated tuberculosis with major rifampicin resistance-conferring mutations.

Nguyen Thi Le Hang,Minako Hijikata,Shinji Maeda,Pham Huu Thuong,Hoang Van Huan,Nguyen Phuong Hoang,Do Bang Tam,Pham Thu Anh, Nguyen Thu Huyen,Vu Cao Cuong,Nobuyuki Kobayashi,Keiko Wakabayashi,Akiko Miyabayashi,Shintaro Seto,Naoto Keicho

Frontiers in microbiology（2023）

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摘要

Our study results showed that mutations as well as Mtb sublineage with additional genetic variants may have significant effects on host response. These findings strengthen the rationale for investigation of host-pathogen interactions to develop countermeasures against epidemics of drug-resistant TB.

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关键词

major rifampicin resistance–conferring,tuberculosis,mutations,host-pathogen

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