Skeletal muscle-specific DJ-1 ablation-induced atrogenes expression and mitochondrial dysfunction contributing to muscular atrophy.

Shuang Zhang,Hongmei Yan,Jiyang Ding,Ruwen Wang,Yonghao Feng,Xinyi Zhang,Xingyu Kong,Hongyu Gong,Xiaodan Lu,Alice Ma,Yinghui Hua, Huan Liu, Jiani Guo,Huanqing Gao,Zhenqi Zhou,Ru Wang,Peijie Chen,Tiemin Liu,Xingxing Kong

Journal of cachexia, sarcopenia and muscle（2023）

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摘要

Our results illuminate the crucial of skeletal muscle DJ-1 in the regulation of catabolic signals from mechanical stimulation, providing a therapeutic target for muscle wasting diseases.

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关键词

mitochondrial dysfunction,skeletal muscle‐specific

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