Generation and Engineering of Potent Single Domain Antibody-Based Bispecific IL-18 Mimetics Resistant to IL-18BP Decoy Receptor Inhibition

Britta Lipinski, Laura Unmuth,Paul Arras,Stefan Becker,Christina Bauer,Lars Toleikis,Simon Krah,Achim Doerner,Desislava Yanakieva,Ammelie Svea Boje,Katja Klausz,Matthias Peipp,Vanessa Siegmund,Andreas Evers,Harald Kolmar,Lukas Pekar,Stefan Zielonka

MABS（2023）

引用 7|浏览22

关键词

Antibody engineering,bispecific antibody,cytokine mimetic,IL-18,IL-18 binding protein,IL-18BP,single domain antibody,surrogate agonist,valencies,VHH,yeast surface display

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