Satellite glial cell-secreted exosomes after in-vitro oxaliplatin treatment presents a pro-nociceptive effect for dorsal root ganglion neurons and induce mechanical hypersensitivity in naïve mice.

Liping Zhao,Shijiang Liu, Xiaobao Zhang,Juan Yang,Mao Mao,Susu Zhang,Shiqin Xu,Shanwu Feng,Xian Wang

Molecular and cellular neurosciences（2023）

引用 0|浏览6

暂无评分

摘要

Our study demonstrates that SGC-secreted exosomes after in-vitro oxaliplatin treatment present a pro-nociceptive effect for DRG neurons and induce mechanical hypersensitivity in naïve mice, possibly via the contained miRNA cargo. Identifying the candidate miRNAs and verifying their functions in vivo are required to elucidate the exosomes mediating 'glia-neuron' communication under CINP condition.

查看译文

关键词

dorsal root ganglion neurons,oxaliplatin treatment,mechanical hypersensitivity,cell-secreted,in-vitro,pro-nociceptive

AI 理解论文

溯源树

样例

生成溯源树，研究论文发展脉络

Chat Paper

正在生成论文摘要