Relationship between circulating mitochondrial DNA and microRNA in patients with major depression.

Haruhiko Ogata,Koichiro Higasa,Yuki Kageyama,Hidetoshi Tahara,Akira Shimamoto,Yoshiteru Takekita,Yosuke Koshikawa,Shinpei Nonen,Tadafumi Kato,Toshihiko Kinoshita,Masaki Kato

Journal of affective disorders（2023）

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摘要

The expression levels of specific miRNAs were associated with ccf-mtDNA copy number in untreated depressed patients; moreover, these miRNAs were linked to antidepressant treatment outcomes. These findings are expected to lead to the elucidation of new pathological mechanism of depression.

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microrna,mitochondrial dna,major depression

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