Randomized Phase II Study of Cpt-11 Vs Ptx; +/- S1 in Advanced Gastric Cancer Refractory to S1 or S1 + Platinum(Ogsg0701)

Background: In Japan, S1 + platinum (SP) is recommended for advanced gastric cancer (AGC) patients as first-line setting, and S1 monotherapy is suggested for frail AGC patients or adjuvant setting. However, taxane or CPT-11 were often employed as second-line treatment for the patients who were resistant to S1-containing regimen. A retrospective analysis has reported that S1 combination chemotherapy extended overall survival as second-line treatment for AGC that was resistant to first-line S1-based chemotherapy.